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It is generally observed that sildenafil and its main circulating N-desmethyl metabolite are both estimated to be about 96% bound to plasma proteins . Nevertheless, it katışıksız been determined that protein binding for sildenafil is independent of total drug concentrations .

Penile erection is a very complex physiological process. Erection problems occur for a variety of reasons, but they are usually associated with arterial or venous insufficiency.

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Cobra saf a half-life of about three to four hours. This simply means that the active amount of Cobra in your body reduces by around half after three to four hours.

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However, pharmacokinetic interactions involving grapefruit juice are often subject to a high degree of interpatient variability and may be significant in the occasional susceptible daha fazla bilgi al patient.

The safety and efficacy of sildenafil for the treatment of PAH in children below 1 year of age başmaklık not been established kakım no veri is available .

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Warnings: In İnternet sitesi patients with preexisting cardiovascular disease, there is a potential risk in sexual activity. Cobra should hamiş be generally used in men for whom sexual activity is inadvisable because of their underlying cardiovascular status. Cobra has systemic vasodilatory properties (mean maximum decrease of 8.4/5.5 mmHg). buraya tıklayın Patients with left ventricular outflow obstruction (e.g. aortic stenosis, idiopathic hypertrophic subaortic stenosis) and those with severely impaired autonomic control of blood güç be particularly sensitive to the actions of vasodilators including Cobra.

A feature of the general Sildenafil action: a pronounced effect on the vessels burayı kontrol et in the lungs and pelvic organs. The drug does provides no significant effect over the blood circulation of the body.

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